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>   home   >   Products   >   Primary Antibodies   >   Glucagon-like Peptide 1 Receptor (extracellular) Antibody   

Glucagon-like Peptide 1 Receptor (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Glucagon-like Peptide 1 Receptor (extracellular) Antibody AG1238-050
    Western blot analysis of rat pancreas lysate (lanes 1 and 5), mouse preadipocyte 3T3-L1 lysate (lanes 2 and 6), rat pancreatic islet cell line RIN-5F lysate (lanes 3 and 7) and human pancreatic carcinoma PANC-1 lysate (lanes 4 and 8): 1-4. Anti-Glucagon-like Peptide 1 Receptor (extracellular) antibody (#AG1238), (1:200).
    5-8. Anti-Glucagon-like Peptide 1 Receptor (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - Glucagon-like Peptide 1 Receptor (extracellular) Antibody AG1238-050
    Expression of glucacon-like peptide receptor 1 in rat pancreas Immunohistochemical staining of rat pancreas paraffin embedded sections using Anti-Glucagon-like Peptide 1 Receptor (extracellular) antibody (#AG1238), (1:100). Staining (brown color) is present in endocrine cells of the Isles of Langerhans. Hematoxilin is used as the counterstain.
  • IHC - Glucagon-like Peptide 1 Receptor (extracellular) Antibody AG1238-050
    Expression of glucagon-like peptide 1 receptor in rat hypothalamus Immunohistochemical staining of rat hypothalamus with Anti-Glucagon-like Peptide 1 Receptor (extracellular) antibody (#AG1238), (1:200). Glucagon-like peptide 1 receptor (green) appears in  the lateral hypothalamic region axonal profiles (vertical arrow) and nerve cell profiles (horizontal arrows) were labeled. DAPI is used as the counterstain (blue).
  • ICC - Glucagon-like Peptide 1 Receptor (extracellular) Antibody AG1238-050
    Expression of glucagon-like peptide receptor 1 in rat pancreatic islet cells Immunocytochemical staining of live intact rat RIN-5F pancreatic islet cells. A. Cells were stained with Anti-Glucagon-like Peptide 1 Receptor (extracellular) antibody (#AG1238), (1:100), followed by goat anti-rabbit-AlexaFluor-594 secondary antibody (red). B. Cell nuclei were visualized with the membrane-permeable DNA dye Hoechst 33342 (blue staining). C. Live view of the cells.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P32301
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 52877 Da
Homology Rat, mouse, human - 13/14 amino acid residues identical.
Additional Information
Gene ID 25021
Other Names Glucagon-like peptide 1 receptor, GLP-1 receptor, GLP-1-R, GLP-1R, Glp1r, Glpr
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)KYLYEDEG(S)WTRNS, corresponding to amino acid residues 288-301 of rat GLP1R (Accession P32301). 2nd extracellular loop.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution Add 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.025% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Citations (0)

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Glucagon-like peptide 1 (GLP-1) is a hormone secreted by the intestine following a meal1. This hormone is known to enhance the secretion of insulin, important to regulate glucose blood levels2,3. In pancreatic b-cells, other than stimulating insulin secretion, GLP-1 action is also important for b-cell mass expansion2. GLP-1 exerts its biological functions through Glucagon-like peptide 1 receptor (GLP-1 receptor), a member of the G-protein coupled receptor superfamily. Like all members this receptor spans the membrane seven times. GLP-1 receptor couples with Gs, thereby stimulates adenylate cyclase which consequently leads to an increase in cAMP2. The receptor is expressed in various tissues, namely the pancreas, adipose tissue, muscle, heart, gastrointestinal tract and liver. GLP-1 receptor is also found in the central nervous system where it provides a neuroprotective effect4. The glucagon-like peptide 1 system may serve as a therapeutic treatment in diabetes mellitus, in order to maintain b-cell mass expansion2. In addition, the receptor may serve as a therapy target in various neurodegenerative diseases like Alzheimer’s and Parkinson’s disease4. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat Glucagon-like peptide 1 receptor.  Anti-Glucagon-like Peptide 1 Receptor (extracellular) antibody (#AG1238) can be used for western blot, immunohistochemical and immunocytochemical applications. It has been designed to recognize Glucagon-like peptide 1 receptor from human, rat and mouse samples.


References 1. Donath, M.Y. et al. (2003) J. Mol. Med. 81, 455. 2. Buteau, J. (2008) Diabetes Metab. 34, S73. 3. Holst, J.J. (2007) Physiol. Rev. 87, 1409. 4. Harkavyi, A. and Whitton, P.S. (2010) Br. J. Pharmacol. 159, 495.

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$ 367.00
$ 475.00
Cat# AG1238-050
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