Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Kainate Receptor GluK4 (extracellular) Antibody   

Kainate Receptor GluK4 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Kainate Receptor GluK4 (extracellular) Antibody AG1243-050
    Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1,2. Anti-Kainate Receptor GluK4 (extracellular) antibody (#AG1243), (1:400).
    3,4. Anti-Kainate Receptor GluK4 (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - Kainate Receptor GluK4 (extracellular) Antibody AG1243-050
    Expression of Kainate receptor GluK4 in rat cerebellar deep nuclei Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-Kainate Receptor GluK4 (extracellular) antibody (#AG1243), (1:100). A. GluK4 staining (red) appears in neurons (arrows) of deep cerebellar nuclei.  B. Cell nuclei in the same section are visualized with DAPI (blue). C. Merge of the two images.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01812
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 107223 Da
Homology Human, mouse - identical.
Additional Information
Gene ID 24406
Other Names Glutamate receptor ionotropic, kainate 4, GluK4, Glutamate receptor KA-1, KA1, Grik4
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)KNRINRAPERLGK, corresponding to amino acid residues 49-61 of rat GluK4 (Accession Q01812). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


Glutamate is the principal excitatory neurotransmitter in the central nervous system (CNS). Glutamate is involved in cognitive functions like learning and memory in the brain.  Imbalances in glutamatergic transmission have profound physiological and behavioral consequences1. Ionotropic glutamate receptors are classified functionally and by molecular homology into three receptor classes: N-methyl-D-aspartate (NMDA), amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), and kainate (KA)2. KA receptors assemble as tetramers from five subunit types, GluK1, GluK2 GluK3, GluK4 and GluK5. The GluK1-GluK3 subunits have low glutamate affinity and are capable of forming functional homomeric channels. GluK4 and GluK5 are high-affinity kainate receptor subunits that bind glutamate but require coassembly with one or more GluK1-GluK3 subunits to form functional channels. The heteromultimeric assembly of kainate receptors like many other ion channels leads to the formation of receptors with unique pharmacological and functional properties3. Unlike the other KA receptor subunits, which are expressed throughout the CNS, GluK4 expression is limited to only a few regions of the brain, and expression is highest in the CA3 region of the hippocampus and dentate gyrus4.   The GluK4 receptor subunit gene, GRIK4, is located near the tip of the long arm of chromosome 11. Genetic variants in the GRIK4 gene have been demonstrated to associate with several psychiatric disorders. GRIK4 has been identified as a susceptibility gene in schizophrenia and bipolar disorder5. GluK4 may also play a role in excitotoxic Neurodegeneration6.


References 1. Krystal, J.H. et al. (1994) Arch. Gen. Psychiatry 51,199. 2. Lodge, D. (2009) Neuropharmacology 56, 6. 3. Lerma, J. et al.  (2001) Physiol. Rev. 81, 971. 4. Bahn, S. et al.  (1994) J. Neurosci. 14, 5525. 5. Pickard, B.S. et al.  (2006)  Mol. Psychiatry 11, 847. 6. Ben-Ari, Y. (1985) Neuroscience 14, 375.

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

$ 367.00
$ 475.00
Cat# AG1243-050
Availability: 2-3 weeks
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Crown Flash21-30% Off
Terms & Conditions