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>   home   >   Products   >   Primary Antibodies   >   GABA(A) gamma1 Receptor Antibody   

GABA(A) gamma1 Receptor Antibody

Affinity purified polyclonal antibody

  • WB - GABA(A) gamma1 Receptor Antibody AG1270-050
    Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates: 1. Anti-GABA(A) γ1 Receptor antibody (#AG1270), (1:500).
    2. Anti-GABA(A) γ1 Receptor antibody, preincubated with the control peptide antigen.
  • IHC - GABA(A) gamma1 Receptor Antibody AG1270-050
    Expression of GABA(A) γ1 Receptor in rat DRG Immunohistochemical staining of rat dorsal root ganglion (DRG) frozen sections using Anti-GABA(A) γ1 Receptor antibody (#AG1270), followed by goat anti-rabbit-AlexaFluor-594 secondary antibody.  A. Staining (red) appears in neuronal cell bodies.  B. Nuclear staining using DAPI as the counterstain.  C. merged image of A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P23574
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 53551 Da
Homology Mouse - 16/18 amino acid residues identical; human - 14/18 amino acid residues identical.
Additional Information
Gene ID 140674
Other Names Gamma-aminobutyric acid receptor subunit gamma-1, GABA(A) receptor subunit gamma-1, Gabrg1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)HAGSTLIPMNNISMPQGE, corresponding to amino acid residues 382-399 of rat GABA(A)־³1 Receptor (Accession P23574 ). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
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The neurotransmitter GABA (γ-aminobutyric acid) inhibits the activity of signal-receiving neurons by interacting with the GABAA receptor on these cells1. There are two major types of GABA receptors: the ionotropic GABAA (GABAA R) and the metabotropic GABAB receptors. GABAA R belongs to the ligand gated ion channel superfamily1,2. The binding of GABA to its GABAA receptor results in conformational changes that open a Cl- channel, producing an increase in membrane conductance, resulting in inhibition of neural activity2,3. They are composed of heteropentamer, with all of the five subunits contributing to the pore formation. To date, eight subunit isoforms have been cloned: α, β, γ, δ, ε, π, θ, and ρ1. The native GABAA receptor, in most cases, consists of 2α, 2β and 1γ subunit. Three γ subunits genes have been identified in mammals. mRNA of the γ1 subunit is detected in the amygdala and septum4.   Abgent is pleased to offer a highly specific antibody directed against an epitope of rat GABA(A) γ1 subunit. Anti-GABA(A) γ1 Receptor antibody (#AG1270) can be used in western blot analysis and was designed to recognize GABA(A) γ1 from human, rat and mouse samples.


References 1. Mihic, S.J. et al. (1994) J.Neurotransmit. Rev. 21, 127. 2. Whiting, P.J. et al. (1999) Neurochem. Int. 34, 379. 3. Ashcroft, F.M. (2000) Ion Channels and Disease Ed 1. 4. Mehta, A.K. and Ticku, M.K. (1999) Brain Res. Rev. 29, 196.

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$ 475.00
$ 575.00
Cat# AG1270-050
(40 western blots)
Availability: 2-3 weeks
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