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>   home   >   Products   >   Primary Antibodies   >   GABA(A) rho1 Receptor (extracellular) Antibody   

GABA(A) rho1 Receptor (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - GABA(A) rho1 Receptor (extracellular) Antibody AG1274-050
    Western blot analysis of rat eye lysate: 1. Anti-GABA(A) ρ1 Receptor (extracellular) antibody (#AG1274), (1:200).
    2. Anti-GABA(A) ρ1 Receptor (extracellular) antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P50572
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 55532 Da
Homology Mouse, human -12/13 amino acid residues identical.
Additional Information
Gene ID 29694
Other Names Gamma-aminobutyric acid receptor subunit rho-1, GABA(A) receptor subunit rho-1, GABA(C) receptor, Gabrr1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)ESTVHWPGREVHE, corresponding to amino acid residues 23-35 of rat ֲ GABA(A) ֿ1 receptor (Accession P50572). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 1 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
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γ-Aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter. It is involved in roughly 40% of the inhibitory synapses1,2. GABA acts through two receptors, GABA(A) and GABA(B). To date, nineteen different GABA(A) subunits have been identified and divided in eight subunits: α (1-6), β (1-3), γ (1-3), δ, ε, ρ (1-3), θ and π. For some of the subunits, alternative splicing further increases the number of existing receptor types. They all have extracellular N- and C-termini and four transmembrane domains1. Three r subunits have been detected: GABA(A) ρ1, GABA(A) ρ2 and GABA(A) ρ3. Like all GABA(A) receptors the ρ subunits also assemble into a pentameric structure forming a Cl- channel. However, in contrast to all other GABA(A) subunits they mostly form homomeric entities. The GABA(A) ρ subunits display different pharmacological characteristics and were therefore once referred to GABA(C) receptors. GABA(A) and GABA(B) respectively respond to bicuculline and baclofen, whereas ρ subunits are insensitive to either drug3-7. In addition, ρ subunits also display different electrophysiological properties, and are significantly more sensitive to GABA3,5,6,8. r subunits are highly expressed in the retina and it was believed that they are only expressed in that area.  They are however, also expressed in central and peripheral nervous systems, as well as in the gastrointestinal and cardiovascular systems1. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat GABA(A) ρ1 subunit. Anti-GABA(A) ρ1 Receptor (extracellular) antibody (#AG1274) can be used in western blot analysis and was designed to recognize GABA(A) ρ1 from human, rat and mouse samples


References 1. Martםnez-Delgado, G. et al. (2010) Curr. Neuropharmacol. 8, 422. 2. Kumar, R.J. et al. (2008) J. Med. Chem. 51, 3825. 3. Bormann, J. (2000) Trends Pharmacol. Sci. 21, 16. 4. Bowery, N.G. (1989) Trends Pharmacol. Sci. 10, 401. 5. Johnston, G.A.R. (1996) Trends Pharmacol. Sci. 17, 319. 6. Bormann, J. and Feigenspan, A. (1995) Trends Neurosci. 18, 515. 7. Cherubini, E. and Strata, F. (1997) News Physiol. Sci. 12, 136. 8. Polenzani, L. et al. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 4318.

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$ 475.00
$ 575.00
Cat# AG1274-050
(40 western blots)
Availability: 2-3 weeks
Bulk Size
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