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>   home   >   Products   >   Primary Antibodies   >   GABA (A) alpha6 Receptor (extracellular) Antibody   

GABA (A) alpha6 Receptor (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - GABA (A) alpha6 Receptor (extracellular) Antibody AG1276-050
    Western blot analysis of rat brain membranes: 1. Anti-GABA(A) α6 Receptor (extracellular) antibody, (1:200).
    2. Anti-GABA(A) α6 Receptor (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - GABA (A) alpha6 Receptor (extracellular) Antibody AG1276-050
    Expression of GABA(A) α6 Receptor in mouse cerebellum
    Immunohistochemical staining of mouse cerebellum using Anti-GABA(A) α6 Receptor (extracellular) antibody (#AG1276). A. GABA(A) α6 Receptor (red) appears in the granule layer (asterisk). B. Parvalbumin (green) appears in Purkinje cells and in the molecular layer. C. Merge of GABA(A) α6 Receptor and parvalbumin indicates that GABA(A) α6 Receptor is restricted to granule cells. DAPI is used as the counterstain (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P30191
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 51184 Da
Homology Mouse- identical; human - 17/19 amino acidresidues identical.
Additional Information
Gene ID 29708
Other Names Gamma-aminobutyric acid receptor subunit alpha-6, GABA(A) receptor subunit alpha-6, Gabra6, Gabra-6
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide QLEDEGNFYSENVSRILDN(C), corresponding to amino acidֲ residues 20-37 of rat GABA(A) ־±6 Receptor (Accessionֲ  P30191). Extracellullar, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.7 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Citations (0)

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GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the brain. Its production, release, reuptake and metabolism occur in the nervous system.1  The GABA transmitter interacts with two major types of receptors: ionotropic GABA(A) and the metabotropic GABA(B) receptors. The GABA(A) receptor belongs to the ligand gated ion channel superfamily.2  The GABA(A) R, is a heteropentamer, with all of its five subunits contributing to the pore formation.  To date, eight subunit isoforms were cloned: α, β, γ, δ, ε, π, θ, and ρ.1  Six α subunit isoforms were described to exist in mammals (α1-α6). The native GABA(A) receptor, in most cases, consists of 2α, 2β and 1γ subunit. The α subunit is the most common subunit and is expressed ubiquitously.   It determines the affinities for allosteric ligands shown by GABA(A)R.  A possible role for the GABA(A) receptors in alcohol action has been derived from animal studies,  in vitro cell models and human research which suggested an important role for GABA(A) α6 along with β2, α1 and γ2, in alcohol related phenotypes.3   In Canavan disease (inherited leukodystrophy), low level of expression of GABA(A) α6 was reported.4 Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat GABA(A) α6 Receptor. The Anti-GABA(A) α6 Receptor (extracellular) antibody (#AG1276) can be used for western blot analysis and Immunohistochemical applications. It has been designed to recognize GABA(A) α6 Receptor from rat, mouse and human samples.


References 1. Owens,D.F. and Kriegstein, A.R. (2002) Nature Rev. Neurosci. 3, 715. 2. Whiting, P.J. (1999) Neurochem. Inter. 34, 387.  3. Loh, E.W and Ball, D. (2000) Neurochem. Int. 37, 413.   4. Surendran, S. et al. (2003) Mol. Gen. Met. 80, 74.

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$ 367.00
$ 475.00
Cat# AG1276-050
Availability: 2-3 weeks
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