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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Cav1.3 (extracellular) Antibody   

Cav1.3 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Cav1.3 (extracellular) Antibody AG1314-050
    Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and C6 (lanes 3 and 6) lysates: 1-3. Anti-Cav1.3 (extracellular) antibody (#AG1314), (1:200).
    4-6. Anti-Cav1.3 (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - Cav1.3 (extracellular) Antibody AG1314-050
    Expression of CaV1.3 in rat DRG Immunohistochemical staining of adult rat dorsal root ganglion (DRG) using Anti-CaV1.3 (extracellular) antibody (#AG1314). A. Cav1.3 labeling (red) appears in the cell bodies of the DRG. B. Nuclear staining using DAPI as the counterstain. C. Merged image of A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P27732
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 250136 Da
Homology Mouse, human - identical.
Additional Information
Gene ID 29716
Other Names Voltage-dependent L-type calcium channel subunit alpha-1D, Calcium channel, L type, alpha-1 polypeptide, isoform 2, Rat brain class D, RBD, Voltage-gated calcium channel subunit alpha Cav13, Cacna1d, Cach3, Cacn4, Cacnl1a2, Cchl1a2
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)EQLTKETEGGNHS, corresponding to amino acid residues 215-227 of rat CaV1.3 (Accession P27732). 2nd extracellular loop, repeat I.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.9 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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All L-type calcium channels are encoded by one of the CaV1 channel genes. These channels play a major role as a Ca2+ entry pathway in skeletal cardiac and smooth muscles as well as in neurons, endocrine cells and possibly in non-excitable cells such as hematopoetic and epithelial cells. All CaV1 channels are influenced by dihydropyridines (DHP) and are also referred to as DHP receptors. While the CaV1.1 and CaV1.4 isoforms are expressed in restricted tissues (skeletal muscle and retina, respectively), the expression of CaV1.2 is ubiquitous.1,2   The CaV1.3 channels are also expressed, as are other L-type channels, in neurons and neuroendocrine cells. However, accumulated data has shown the expression of CaV1.3 in heart and suggests that it plays a major role in the generation of cardiac pacemaker activity.3,4   Several peptidyl toxins have been described that are specific L-type channel blockers. These include the Mamba toxins Calcicludine (#C-650), Calciseptine (#C-500) and FS-2 (#F-700). So far no selective blocker for one of the CaV1 isoforms has been described.


References 1. Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579. 2. IUPHAR 3. Mangoni, M.E. et al. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 5543. 4. Zhang, Z. et al. (2005) Circulation 112, 1936.

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$ 475.00
$ 575.00
Cat# AG1314-050
(40 western blots)
Availability: 2-3 weeks
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