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CaVBeta1 Antibody

Affinity purified polyclonal antibody

  • WB - CaVBeta1 Antibody AG1324-025
    Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and rat cortex (lane 3 and 6): 1-3. Anti-CaVβ1 antibody (#AG1324), (1:800).
    4-6. Anti-CaVβ1 antibody preincubated with the control peptide antigen.
  • IHC - CaVBeta1 Antibody AG1324-025
    Expression of CaVβ1 in rat hippocampus Immunohistochemical staining of rat hippocampus using Anti-CaVβ1 antibody (#AG1324). A. Cavβ1 staining (red) appears in dendrites of the stratum radiatum (arrow).  B. Nuclear staining using DAPI as the counterstain (blue). C. Merge image of A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P54283
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 65680 Da
Homology Mouse – identical; human - 14/16.
Additional Information
Gene ID 50688
Other Names Voltage-dependent L-type calcium channel subunit beta-1, CAB1, Calcium channel voltage-dependent subunit beta 1, Cacnb1, Cacnlb1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)DRATGEHASVHEYPGE, corresponding to amino acid residues 456-471 of rat CaV־²1 (Accession P54283). Intracellular, adjacent to the C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.85 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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Voltage-gated Ca2+ (CaV) channels are ubiquitously expressed and function as Ca2+ conducting pores in the plasma membrane1. Based on their electrophysiological and pharmacological properties, CaV channels have traditionally been classified into L, T, N, P, Q, and R types2. L-type Ca2+ channels are heteromultimers composed of four independently encoded proteins, the pore-forming α1 subunit, which triggers Ca2+ flow across the membrane, and the subunits α2δ, γ, and β3.    CaVβ subunits play critical roles in membrane trafficking of the channel complex and regulation of voltage-dependent gating. The CaVβ subunit binds to the endoplasmic reticulum (ER) retention signal in the I-II loop of the α1-subunit, which allows channels to traffic to the surface membrane4. Furthermore, CaVβ subunits not only allow for membrane trafficking of the channel complex, they also can play a role in determining the subcellular localization of channels on the surface membrane5.  There are four distinct CaVβ subunits CaVβ1, CaVβ2, CaVβ3 and CaVβ46.   Three splice variants exist for the β1 subunit: β1a, β1b and β1c. β1a is known to be expressed in skeletal muscle and brain, but not in smooth muscle or heart. β1a appears to be important for the functional expression of the α1 subunit in skeletal muscle7. β1b was identified by cloning in rat brain, heart and hippocampus, and differs from β1a by having a deletion of ~50 amino acids at residue 209, and having a 120-residue C-terminal elongation. β1c was cloned from human heart and hippocampus and has the same deletion as β1b, but lacks the C-terminal extension.


References 1. Catterall, W.A. et al. (2000) Annu. Rev. Cell. Dev. Biol. 16, 521. 2. Qin, N. et al. (2002) Mol. Pharmacol. 62, 485. 3. De Jongh, K.S. et al. (1990)   J. Biol. Chem. 265, 14738. 4. Bichet, D. et al.  (2000) Neuron 25, 177. 5. Foell, J.D. et al. (2004) Physiol. Genomics 17, 183. 6. Dolphin, A.C. (2003) J. Bioenerg. Biomembr. 35, 599. 7. Beurg, M. et al. (1999) Biophys J. 77, 2953.

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Cat# AG1324-025
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