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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Calcium Homeostasis Modulator 1 Antibody   

Calcium Homeostasis Modulator 1 Antibody

Affinity purified polyclonal antibody

  • WB - Calcium Homeostasis Modulator 1 Antibody AG1327-050
    Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5), U-87 MG (lanes 3 and 6) and C6 (lanes 4 and 8) lysates:

    1. Anti-Calcium Homeostasis Modulator 1 antibody (#AG1327), (1:200).
    2. Anti-Calcium Homeostasis Modulator 1 antibody, preincubated with the control peptide antigen.

  • IHC - Calcium Homeostasis Modulator 1 Antibody AG1327-050
    Expression of Calcium Homeostasis Modulator 1 in rat hippocampus Immunohistochemical staining of rat hippocampus using Anti-Calcium Homeostasis Modulator 1 antibody (#AG1327).  A. Staining of Calcium Homeostasis Modulator 1 appears only in the hippocampal CA1 pyramidal layer (red).  B. Nuclear staining using DAPI as the counterstain (blue).  C. Merge of A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IU99
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 38264 Da
Homology Rat, mouse - identical.
Additional Information
Gene ID 255022
Other Names Calcium homeostasis modulator protein 1, Protein FAM26C, CALHM1, FAM26C
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)EAMNHDLELGHTHG, corresponding to amino acid residues 252-265 of human calcium homeostasis modulator protein 1 (Accession Q8IU99). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and mass-spectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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A misbalance in Ca2+ homeostasis seems to be related to the development of Alzheimer’s disease (AD). Indeed Neuronal Ca2+ balance may affect the levels of proteins associated with AD, such as amyloid-beta (Ab) and tau1. Calcium homeostasis modulator 1 (CALHM1) is a cerebral Ca2+ channel component responsible for controlling intracellular Ca2+ levels and Ab metabolism2,3. CALHM1 is a three transmembrane glycoprotein, mostly localized to the endoplasmic reticulum (ER) although it can be detected at the plasma membrane. A functional channel is formed by multiple subunits which has some structural similarities to the NMDA receptor. It is expressed in all brain regions1. In cultured cells, overexpression of CALHM1 increases intracellular Ca2+ levels and reduces Ab accumulation, thereby reinforcing its implication in the development of AD. Indeed, a polymorphism in the gene was found to affect the onset of AD2. Abgent is pleased to offer a highly specific antibody directed against an epitope of human calcium homeostasis modulator 1. Anti-Calcium Homeostasis Modulator 1 antibody (#AG1327) can be used in western blot and immunocytochemistry applications. It has been designed to recognize calcium homeostasis modulator 1 from rat, mouse and human samples.


References 1. Green, K.N. and LaFerla, F.M. (2008) Neuron 59, 190. 2. Koppel, J. et al. (2011) Mol. Med. 17, 974. 3. Dreses-Werringloer, U. et al. (2008) Cell 133, 1149.

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$ 367.00
$ 475.00
Cat# AG1327-050
Availability: 2-3 weeks
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