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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TRPV6 Antibody   

TRPV6 Antibody

Affinity purified polyclonal antibody

  • WB - TRPV6 Antibody AG1347-025
    Western blot analysis of  PC-3 cell lysate:
    1. Anti-TRPV6 antibody (#AG1347), (1:200).
    2. Anti-TRPV6 antibody, preincubated with the control peptide antigen.
  • IHC - TRPV6 Antibody AG1347-025
    Expression of TRPV6 in rat DRG
    Immunohistochemical staining of rat dorsal root ganglion (DRG) using Anti-TRPV6 antibody (#AG1347), (1:100). A. TRPV6 channel (red) in DRG neurons. B. Staining with mouse anti-Parvalbumin (green) in the same DRG section.  C. Confocal merge of TRPV6 and Parvalbumin demonstrates colocalization (arrows).
  • ICC - TRPV6 Antibody AG1347-025
    Expression of TRPV6 in PC-3 cells  Immunocytochemical staining of paraformaldehyde-fixed PC-3 cells with Anti-TRPV6 antibody (#AG1347), (1:100) followed by goat anti-rabbit-AlexaFluor-555 secondary antibody (A) or with a mixture of Anti-TRPV6  and TRPV6 peptide antigen (1:20) (B). Hoechst 33342 is used as the counterstain (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9H1D0
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 87286 Da
Homology Rat, mouse - 13/14 amino acid residues identical.
Additional Information
Gene ID 55503
Other Names Transient receptor potential cation channel subfamily V member 6, TrpV6, CaT-like, CaT-L, Calcium transport protein 1, CaT1, Epithelial calcium channel 2, ECaC2, TRPV6, ECAC2
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)NRGLEDGESWEYQI, corresponding to amino acid residues 712-725 of human TRPV6 (Accession Q9H1D0).ֲ ֲ Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and mass-spectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.75 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.1 According to IUPHAR the TRP family comprises of three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP).1-4 The TRPV subfamily consists of six members, TRPV1-6.5 TRPV6 (CaT1) and TRPV5 (ECaC) are unique members of the TRP family. Both are epithelial calcium channels, form constitutively open channels, share high degree of homology (about 66%) with differences in the N and C-terminus. TRPV6 and TRPV5 are expressed in a 1,25-dihydroxyvitamin D3 dependent manner. In contrast to other members of the TRP family, TRPV6 and TRPV5 are highly Ca2+ selective and are expressed in Ca2+ transporting epithelia where they are assumed to have an important role in Ca2+ reabsorption. TRPV6 is highly expressed in the placenta, small intestine and kidney.6,7 While not being expressed in benign prostate tissue, TRPV6 was found to be upregulated in prostate cancer tissue and correlation between expression and tumor grade was shown.  Finally, TRPV6 was suggested as prognostic marker and as a promising candidate for therapeutic strategies.8,9 Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of the human TRPV6. Anti-TRPV6 antibody (#AG1347) can be used in western blot analysis, immunoprecipitation,  immunocytochemical and immunohistochemical applications. It has been designed to recognize TRPV6 from human, rat and mouse samples.


References 1. Montell, C. et al. (2002) Mol. Cell. 9, 229. 2. Clapham, D.E. (2003) Nature 426, 517. 3. Moran, M.M. et al. (2004) Curr.Opin.Neurobiol. 14, 362. 4. Clapham, D.E. et al. (2003) Pharmacol. Rev. 55, 591. 5. Gunthorpe, al. (2002) Trends. Pharmacol. Sci. 23, 183. 6. Hoenderop, J.G.J. et al. (2003) Pflugers Arch 446, 304. 7. Peng, J-B. et al. (2003) J. Physiol. 551, 729. 8. Fixemer, T. et al. (2003) Oncogene 22, 7858 9. Wissenbach, U. et al. (2001) J. Biol. Chem. 276, 19461.

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1347-025
(40 western blots)
Availability: 2-3 weeks
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