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beta2-Adrenoceptor (extracellular) Antibody

Affinity purified rabbit polyclonal antibody

  • WB - beta2-Adrenoceptor (extracellular) Antibody AG1380-025
    Western blot analysis of rat heart (lanes 1 and 3) and lung (lanes 2 and 4) lysates: 1, 3. Anti-β2-Adrenoceptor (extracellular) antibody (#AG1380), (1:200). 2, 4. Anti-β2-Adrenoceptor (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - beta2-Adrenoceptor (extracellular) Antibody AG1380-025
    Expression of β2-Adrenoceptor in rat lung Immunohistochemical staining of paraffin-embedded section of rat lung using Anti-ß2-Adrenoceptor (extracellular) antibody (#AG1380), (1:100). ß2-Adrenoceptor is expressed in the respiratory epithelium. Hematoxilin is used as the counterstain.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P18762
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 46998 Da
Homology Human - 15/16 amino acid residues identical; rat - 14/16 amino acid residues identical.
Additional Information
Gene ID 11555
Other Names Beta-2 adrenergic receptor, Beta-2 adrenoreceptor, Beta-2 adrenoceptor, Adrb2, Adrb2r
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)NGSRAPDHDVTQERDE, corresponding to amino acid residues 15-30 of  mouse ־²2-Adrenoceptor (Accession  P18762).   Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and massspectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.7 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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Adrenoceptors (also called adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions. The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: α1, α2 and β-Adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β3. 1,2 The Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system.1,2 β2-Adrenoceptors are mainly postsynaptic receptors. They are expressed on a number of tissues including blood vessels, bronchi, gastrointestinal tract (GIT), skeletal muscle, liver and mast cell.3 Functional β2-Adrenoceptors were also found on lymphocytes, macrophages and neutrophils.4,5 They are also the only β-Adrenoceptor subtype expressed in keratinocytes, fibroblasts and melanocytes.3 Activation of β2-Adrenoceptors results in vasodilation, relaxation of the GIT, inhibition of histamine release from mast cells and bronchodilation. Selective agonists of β2-Adrenoceptors are used to treat asthma and other related bronchospastic conditions such as Chronic obstructive pulmonary disease (COPD).5 Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the mouse β2-Adrenoceptor. Anti-β2-Adrenoceptor (extracellular) antibody (#AG1380) can be used in western blot and immunohistochemistry applications. It has been designed to recognize β2-Adrenoceptor from mouse, rat and human samples.


2. Piascik, M. T .and Perez, D. M. (2001) J. Pharmacol. Exp. Ther. 298, 403.
3. Pullar, C.E. et al. (2006) FASEB J. 20, 76.
4. Oostendorp, J. et al (2005) Am. J. Respir. Crit. Care Med. 172, 322.
5. Giembycz, M. A. and Newton, R. (2006) Eur. Respir. J. 27, 1286.

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Cat# AG1380-025
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