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TMC6 (EVER1) Antibody

Affinity purified polyclonal antibody

  • WB - TMC6 (EVER1) Antibody AG1387-025
    Western blot analysis of rat prostate (lanes 1and 4), rat testis (lanes 2 and 5) and rat placenta (lanes 3 and 6): 1-3. Anti-TMC6 (EVER1) antibody (#AG1387), (1:800).
    4-6. Anti-TMC6 (EVER1) antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z403
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 90045 Da
Homology Rat, mouse - 13/14 amino acid residues are identical.
Additional Information
Gene ID 11322
Other Names Transmembrane channel-like protein 6, Epidermodysplasia verruciformis protein 1, Protein LAK-4, TMC6, EVER1, EVIN1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CGPFRTLDTMYEAGR, corresponding to amino acid residues 681-695 of human TMC6 (Accession Q7Z403). Intracellular, Cytoplasm.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.85 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Resuspended antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
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EVER gene belongs to larger family of proteins referred to as the transmembrane channel-like protein (TMC) family1.  EVER1/TMC6 protein, integral membrane protein, is located in the endoplasmic reticulum (ER) of keratinocytes, where it forms a complex with zinc transporter-1 (ZnT-1) a membrane protein responsible for zinc efflux and resistance to zinc toxicity, thereby controlling the cellular zinc balance2. The EVER1 protein is predicted to have 10 transmembrane domains and 2 leucine zipper motifs1.   The EVER1 gene encodes 2 alternatively spliced proteins, one of 805 amino acids and the other of 454 amino acids, in the same open reading frame. The EVER genes are thought to be transcribed in numerous tissues including the skin1. Mutations in the TMC6 are implicated in the development of the rare autosomal recessive disease Epidermodysplasia Verruciformis (EV)3. EV is characterized by extreme susceptibility to infection by cutaneous human papillomaviruses (HPV) of the beta genus. The TMC6 genes may be involved in controlling HPV gene expression and replication in epidermal keratinocytes or they may directly affect innate and adaptive immune responses which control the clearance of HPV-infected keratinocytes in EV cases4. A recent report indicated an association between genetic variation in the TMC6 region and development of cervical cancer (CxCa) 5.


References 1. Lazarczyk, M. et al. (2009) Microbiol. Mol. Biol. Rev. 73, 348. 2. Lazarczyk, M. et al. (2008) J. Exp. Med. 205, 35. 3. Ramoz, N. et al. (2002) Nat. Genet.  32, 579. 4. Orth, G. et al. (2008) Curr. Top Microbiol. Immunol. 321, 59. 5. Castro, F.A. et al. (2012) Int. J. Cancer 130, 349.

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Cat# AG1387-025
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