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NaVBeta1 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - NaVBeta1 (extracellular) Antibody AG1388-025
    Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and rat skeletal muscle (lanes 3 and 6): 1-3. Anti-NaVβ1 (extracellular) antibody (#AG1388), (1:400).
    4-6. Anti-NaVβ1 (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - NaVBeta1 (extracellular) Antibody AG1388-025
    Expression of NaVβ1 in rat DRG Immunohistochemical staining of adult rat dorsal root ganglion (DRG) using Anti- NaVβ1 (extracellular) antibody (#AG1388) followed by goat anti-rabbit-AlexaFluor-594 secondary antibody. A. Navβ1 labeling (red) appears in the cell bodies of the DRG neurons. B. Nuclear staining using DAPI as the counterstain (blue). C. Merged image of A and B.
  • ICC - NaVBeta1 (extracellular) Antibody AG1388-025
    Expression of NaVβ1 in differentiated rat PC12 cells Immunocytochemical staining of live and intact differentiated rat PC12 cells. PC12 differentiation was induced by mNGF 2.5S (>95%) (#N-100). A, C. Merge of NaVβ1 staining using Anti-NaVβ1 (extracellular) antibody (#AG1388), (1:50), (red) with live cell imaging.  B, D. Merge of NaVβ1 staining (1:50), (red) with nuclear staining using DAPI as the counterstain.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00954
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24692 Da
Homology Mouse - identical; human -13/14 amino acid residues identical.
Additional Information
Gene ID 29686
Other Names Sodium channel subunit beta-1, Scn1b
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CKRRSETTAETFTE, corresponding to amino acid residues 43-56 of rat Nav־²1 (Accession Q00954). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.85 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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Voltage-gated sodium channels (Nav) are essential for the generation of action potentials and for cell excitability.1 To date, nine Nav α subunits have been cloned and named Nav1.1-Nav1.9.2,3  Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β-subunits (Nav β-subunit).4   The Nav β-subunit gene family consists of four members: β1 (SCN1B), β2 (SCN2B), β3 (SCN3B), and β4 (SCN4B) having type I topology, containing an extracellular amino-terminus, a single transmembrane segment, and an intracellular carboxyl-terminus.They modulate channel gating, assembly, and cell surface expression in heterologous cell systems.5   Navβ-subunits are cell adhesion molecules of the Ig superfamily, which interact with extracellular matrix, transmembrane signaling, and cell adhesion molecules.5 In the adult central nervous system and heart, sodium channels are associate with β1- β4 subunits, whereas in adult skeletal muscle they are associate only with the β1 subunit.4,5 This association appears to be a late event in sodium channel biosynthesis.6


References 1. Wu, L. et al. (2002) NeuroReport 13, 2547. 2. Baker, M.D. and Wood, J.N. (2001) Trends Pharmacol. Sci. 22, 27. 3. Lai, J. et al. (2003) Curr.Opin. Neurobiol 13, 291. 4. Catterall, W.A. (2000) Neuron 26, 13. 5. Chen, C. et al. (2002) Proc. Natl. Acad. Sci. U.S.A.  99, 17072. 6. Schmidt, J.W. and Catterall, W.A. (1986) Cell 46, 437. 7. Lopez-Santiago L. F. et al. (2006) J. Neurosci. 6, 7984.

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Cat# AG1388-025
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