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P2Y6 Receptor Antibody

Affinity purified polyclonal antibody

  • WB - P2Y6 Receptor Antibody AG1400-025
    Western blot analysis of rat brain (lanes 1, 3) and rat heart (lanes 2, 4) lysates: 1, 2. Anti-P2Y6 Receptor antibody (#APC-011), (1:200). 
    3, 4. Anti-P2Y6 Receptor antibody, preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63371
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 36677 Da
Homology Mouse - 17/18 amino acid residues identical; human - 15/18 amino acid residues identical.
Additional Information
Gene ID 117264
Other Names P2Y purinoceptor 6, P2Y6, P2ry6
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CQPHDLLQKLTAKWQRQRV, corresponding to amino acid residues 311-328 of rat P2Y6 receptor (Accession number Q63371). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and mass-spectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.75 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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The nucleotide receptor P2Y6 binds UDP, and is a member of the G-protein coupled receptor superfamily.1,3 P2Y6 agonists induce an inositol phosphate/Ca2+ response that is insensitive to pertussis toxin inhibition. P2Y6 is coupled to phospholipase C via Gq, and is also coupled to inhibition of N-type Ca2+ and M-type K+ channels.1,2 P2Y6 mRNA is expressed in various rat tissues, including lung, stomach, intestine, spleen, heart, and aorta. P2Y6 was reported to mediate contractions in human cerebral arteries.4 Abgent is please to offer a highly specific antibody directed against the C-terminus domain of the rat P2Y6 receptor. Anti-P2Y6 Receptor antibody (#AG1400) can be used in western blot analysis, indirect flow cytometry, immunoprecipitation, immunocytochemistry and immunohistochemistry. It has been designed to recognize P2Y6 from rat, mouse and human samples.


References 1. Communi, D. et al. (2000) Cell Signal. 12, 351. 2. Filippov, A.K. et al. (1999) Br. J. Pharmacol. 270, 26152. 3. Chang, K. et al. (1995) J. Biol. Chem. 270, 26152.  4. Malmsjo, M. et al. (2003) B.M.C. Pharmacol. 3, 4. 

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1400-025
(40 western blots)
Availability: 2-3 weeks
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