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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   KV7.1 (KCNQ1) Antibody   

KV7.1 (KCNQ1) Antibody

Affinity purified polyclonal antibody

  • WB - KV7.1 (KCNQ1) Antibody AG1407-025
    Western blot analysis of rat heart membranes: 1. Anti-Kv7.1 (KCNQ1) antibody (#AG1407), (1:200).   
    2. Anti-Kv7.1 (KCNQ1) antibody, preincubated with the control peptide antigen
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P51787
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 74699 Da
Homology Rat, mouse - 14/16 amino acid residues identical.
Additional Information
Gene ID 3784
Other Names Potassium voltage-gated channel subfamily KQT member 1, IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv71, KCNQ1, KCNA8, KCNA9, KVLQT1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)TYEQLTVPRRGPDEGS, corresponding to amino acid residues 661-676 of human Kv7.1 (Accession number P51787). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Application Details Western blot analysis (WB): - MDCK cells stably expressing human KV7.1 (1:1000) See Andersen, M.N. et al. (2013) in Product Citations). - Xenopus oocyte membrane lysates (1:500), (see Lundby, A. et al. (2013) in Product Citations). Immunoprecipitation (IP): - Canine left ventricle (8 μg) (see Ehrlich, J.R. et al. (2004) in Product Citations). Immunohistochemistry (IH): - Guinea pig detrusor (1:200) (see Anderson, U.A. et al. (2013) in Product Citations). - Mouse distal colon (1:50) (see Jepps, T.A. et al. (2009) in Product Citations). Immunocytochemistry (IC): - COS cells (see Wiener, R. et al. (2008) in Product Citations).  
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.75 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 2.5 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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KV7.1 (KCNQ1) is part of a voltage-gated K+ family that includes 5 other members (KCNQ1-5).   The channel has been intensively studied since it was found that together with MinK (Isk) it underlay the cardiac Iks current that controls the duration of the action potential of the human heart.   Indeed mutations on either KV7.1 or MinK can be responsible for long QT syndrome, a cardiac disorder that causes arrhythmias and sudden death.  Although KV7.1 expression and function has been mainly investigated in relation with cardiac function the channel is widely distributed in epithelial tissues. There it has been implicated in physiological functions such as: regulation of acid secretion in the stomach and Cl- secretion into the colon.


References 1. Wang, Q. et al. (1996) Nat. Genet. 12, 17. 2. Grahammer, F. et al. (2001) Gastroenterology 120, 1363. 3. Mall, M. et al. (1998) Am. J. Physiol. 275, G1274.

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1407-025
(40 western blots)
Availability: 2-3 weeks
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