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mu-Opioid Receptor (extracellular) Antibody

Affinity purified rabbit polyclonal antibody

  • WB - mu-Opioid Receptor (extracellular) Antibody AG1412-025
    Western blot analysis of rat hippocampus lysate: 1. Anti-µ-Opioid Receptor (extracellular) antibody (#AG1412), (1:200). 2. Anti-µ-Opioid Receptor (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - mu-Opioid Receptor (extracellular) Antibody AG1412-025
    Expression of µ-opioid receptor (MOR-1) in rat spinal cord Immunohistochemical staining of rat spinal cord frozen section using Anti-µ-Opioid Receptor (extracellular) antibody (#AG1412), (1:100), followed by goat anti-rabbit AlexaFluor-488 secondary antibody (green). Staining is present in both neuronal cell bodies (white arrows) and their prolongations (red arrows). Hoechst 33342 is used as the counterstain (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P33535
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 44494 Da
Homology Mouse - identical; human - 15/17 amino acid residues identical.
Additional Information
Gene ID 25601
Other Names Mu-type opioid receptor, M-OR-1, MOR-1, Opioid receptor B, Oprm1, Ror-b
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide CSPAPGSWLNLSHVDGN, corresponding to amino acid residues 22-38 of the rat µ-Opioid receptor (Accession P33535). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis and mass-spectrography.
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Buffer After Reconstitution Phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Research Areas
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Endogenous opiates such as endorphins, endomorphins, and enkephalins, as well as opiate drugs (including morphine) exert their effects by binding to opioid receptors. Three "classic" types of opioid receptors have been identified: mu (µ)-opioid (MOP) receptor, delta (δ)-opioid (DOP) receptor, and kappa (κ)-opioid (KOP) receptor.1 Recently, the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor was also described. Despite its significant sequence homology, its pharmacological profile differs greatly from those of the classic µ, δ, and κ receptors.2 The opioid receptors belong to the G protein-coupled receptor (GPCR) superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop important for binding G proteins.1 All three receptors mediate opioid-induced analgesia. Supraspinal analgesia is mainly mediated by the µ-receptors, whereas µ-, δ-, and κ-receptors participate in the control of pain at the spinal level. These receptors also mediate the mood-altering properties of opioids.3 Of the opioid receptors, the µ-opioid receptor has been the most extensively studied due to its important role in mediating the actions of morphine and other analgesic agents, as well as other addictive drugs such as heroin.1 The µ-opioid receptors are expressed in the central nervous system (CNS) and in the peripherial nervous system.4 The highest densities are found in the thalamus, caudate putamen, neocortex, amygdala, and other brain regions known to have well established roles in pain and analgesia.5


1. Pan, L. et al. (2005) Neuroscience 133, 209.
3. Matthes, H.W. et al. (1998) J. Neurosci. 18, 7285.
4. Shaqura, M.A. et al. (2004) J. Pharmacol. Exp. Ther. 308, 712.
5. Baraldi, P.G. et al. (2006) Curr. Med. Chem. 13, 3467.

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1412-025
(40 western blots)
Availability: 2-3 weeks
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