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>   home   >   Products   >   Primary Antibodies   >   Neuroligin 2 (extracellular) Antibody   

Neuroligin 2 (extracellular) Antibody

Affinity purified polyclonal antibody

  • WB - Neuroligin 2 (extracellular) Antibody AG1419-025
    Western blot analysis of rat brain membrane (lanes 1 and 4), mouse brain membrane (lanes 2 and 5) and rat PC-12 cells (lanes 3 and 6): 1-3. Anti-Neuroligin 2 (extracellular) antibody (#AG1419), (1:400).
    4-6. Anti-Neuroligin 2 (extracellular) antibody preincubated with the control peptide antigen.
  • IHC - Neuroligin 2 (extracellular) Antibody AG1419-025
    Expression of Neuroligin 2 in rat DRG Immunohistochemical staining of adult rat dorsal root ganglion (DRG) using Anti-Neuroligin 2 (extracellular) antibody (#AG1419) followed by goat anti-rabbit-AlexaFluor-594 secondary antibody.  
    A. Neuroligin 2 labeling (red) appears in the cell bodies of the DRG neurons. B. Nuclear staining using DAPI as the counter stain (blue). C. Merged image of A and B.
  • IHC - Neuroligin 2 (extracellular) Antibody AG1419-025
    Expression of Neuroligin-2 in rat brain Immunnohistochemical staining of rat reticular thalamic nucleus using Anti-Neuroligin-2 (extracellular) antibody (#AG1419).  A. Neuroligin-2  staining (red) is detected in neuronal outlines (arrow).  B. Nucleus staining using DAPI as the counterstain. C. Merged images od A and B.
  • ICC - Neuroligin 2 (extracellular) Antibody AG1419-025
    Expression of Neuroligin 2 in rat PC-12 cells Immunocytochemical staining of intact living rat PC-12 cells.
    A. Extracellular staining of cells using Anti-Neuroligin 2 (extracellular) antibody (#AG1419), (1:25), followed by goat anti-rabbit-AlexaFluor-594 secondary antibody (red). B. Nuclear staining using DAPI as the counterstain (blue). C. Merged images of A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q62888
Reactivity Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 90961 Da
Homology Mouse - identical; human - 12/14.
Additional Information
Gene ID 117096
Other Names Neuroligin-2, Nlgn2
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)DLGPRAYDRFPGDS, corresponding to amino acid residues 657-670 of rat Neuroligin 2 (Accession Q62888). Extracellular, N-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by mass-spectrography and amino acid analysis.
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.85 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl DDW.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Citations (0)

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Neuroligins (NLGNs) are family of postsynaptic cell adhesion molecules that play an important role in synaptic development and function1. Four genes encode for the different members of the neuroligin family in mammals: NLGN 1-4, which are differentially enriched in postsynaptic specializations of synapses2. Neuroligin 2 (NLGN2) is expressed in neurons in the brain and also in pancreatic β cells where it facilitates insulin secretion3.   Synaptic maturation is promoted by the binding of Neuroligin 2 with presynaptic Neurexins, and these interactions are restricted to particular combinations of isoforms of the binding partners3. NLGN2 plays a role in synapse function and synaptic signal transmission, especially via γ-aminobutyric acid receptors (GABA(A) receptors). NLGN2 modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing4.   Recent studied identified a loss-of-function mutation of NLGN2 in schizophrenia patients, suggesting an indispensable role of NLGN2 in regulating GABAergic functions5.


References 1. Chubykin, A.A. et al. (2007) Neuron 54, 919. 2. Kohl, C. et al. (2013) PLoS ONE 8, e5687. 3. Suckow, A.T. et al. (2008) Endocrinology 149, 6006. 4. Lee, K. et al. (2013) Proc. Natl. Acad. Sci. U.S.A. 110, 336. 5. Sun C. et al. (2011) Hum. Mol. Genet. 20, 3042.

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Cat# AG1419-025
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