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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   TRPV1 Antibody   

TRPV1 Antibody

Affinity purified polyclonal antibody

  • WB - TRPV1 Antibody AG1452-025
    Western blot analysis of TRPV1 transfected HEK-293 cells:
    1. Anti-TRPV1 antibody (#AG1452), (1:200).
    2. Anti-TRPV1 antibody, preincubated with the control peptide antigen.
  • WB - TRPV1 Antibody AG1452-025
    Western blot analysis of rat DRG lysate: 1. Anti-TRPV1 antibody (#AG1452), (1:200).
    2. Anti-TRPV1 antibody, preincubated with the control peptide antigen.
  • IHC - TRPV1 Antibody AG1452-025
    Expression of TRPV1 in rat DRG
    Immunohistochemical staining of rat dorsal root ganglion (DRG) using Anti-TRPV1 antibody (#AG1452). A. TRPV1 (red) in DRG neurons. B. Staining with mouse anti-Parvalbumin (green) in the same DRG section. C. Confocal merge of TRPV1 and Parvalbumin demonstrates colocalization (arrows).
  • ICC - TRPV1 Antibody AG1452-025
    Expression of TRPV1 in rat DRG primary culture
    Immunocytochemical staining of paraformaldehyde-fixed and permeabilized rat dorsal root ganglia (DRG) primary cells with Anti-TRPV1 antibody (#AG1452), (1:200). A. Staining followed by goat anti-rabbit-AlexaFluor-555 secondary antibody. B. Nuclear staining using the cell-permeable dye Hoechst 33342. C. Merged image of panels A and B.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O35433
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 94948 Da
Homology Guinea pig - 14/15 amino acid residues identical; human - 10/15 amino acid residues identical.
Additional Information
Gene ID 83810
Other Names Transient receptor potential cation channel subfamily V member 1, TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, Vanilloid receptor type 1-like, Trpv1, Vr1, Vr1l
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Target/Specificity Peptide (C)EDAEVFKDSMVPGEK, corresponding to amino acid residues 824-838 of rat TRPV1 (Accession O35433). Intracellular, C-terminus.
Dilution WB~~1:200-1:2000
Peptide Confirmation Confirmed by amino acid analysis.
Application Details Immunohistochemistry (IH): - Human uveal melanoma sections (1:200) (see Mergler, S. et al. (2014) in Product Citations). - Rat DRG sections (1:1000) (see Isensee, J. et al. (2014) in Product Citations). - Human skin sections (1:1000) (see Cheng, H.T. et al. (2013) in Product Citations).
Format Affinity purified antibody, lyophilized powder
Reconstitution 25 µl, 50 µl or 0.2 ml deionized water, depending on the sample size.
Antibody Concentration After Reconstitution 0.8 mg/ml.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Reconstitution 100 µl water.
Control Antigen Storage After Reconstitution-20ºC.
Preadsorption Control 1 µg peptide per 1 µg antibody.
Formulation Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Research Areas
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TRPV1 (also named VR1, capsaicin receptor and vanilloid receptor) is a member of the transient receptor potential (TRP) channel family, which includes TRPC, TRPM, TRPA, TRPP, TRPML and the TRPV subfamilies. The TRPV subfamily consists of six members named, TRPV1-6. The TRPV1 channel is a vanilloid gated, nonselective cation channel. The channel has sequence homology to the TRP family, and shares a similar predicted structure of six transmembrane domain (TM) with a pore loop between TM5 and TM6.1 TRPV1 is expressed predominantly in nociceptors and in sensory neurons.2,3 TRPV1 has many activators among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.5,6 Other members of this family, TRPV2, TRPV3 and TRPV4 also show thermal sensitivity.7 Conformational changes in the C-terminus are responsible for many functions such as permeation and gating. There is also evidence that deletion of the C-terminus causes a loss of sensitivity to any stimuli.7 Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis.8,9


References 1. Gunthorpe, M.J. et al. (2002) Trends Pharmacol. Sci. 23, 183. 2. Cesare, P. et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 7658. 3. Kim, J. et al. (2003) Nature 424, 81. 4. Ahern, G. P. et al. (2003) J. Biol. Chem. 278, 30429.  5. Ross, R.A. et al. (2003) Br. J. Pharmacol. 140, 790. 6. Tominaga, M. et al. (1998) Neuron 21, 531. 7. Vlachova, V. et al. (2003) J. Neurosci. 23, 1340. 8. Agopyan, N. et al. (2004) Am. J. Physiol. 286, L563. 9. Reilly, C.A. et al. (2003) Toxicol. Sci. 73, 170.

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Cat# AG1452-025
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