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>   home   >   Products   >   Primary Antibodies   >   Neurexin 1alpha (extracellular) Antibody   

Neurexin 1alpha (extracellular) Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Neurexin 1alpha (extracellular) Antibody AG1537-025
    Western blot analysis of rat brain (lanes 1 and 3) and mouse brain (lanes 2 and 4) lysates:1,2.Anti-Neurexin 1α (extracellular) antibody (#AG1537), (1:400).3,4. Anti-Neurexin 1α (extracellular) antibody, preincubated with the control peptide antigen.
  • ICC - Neurexin 1alpha (extracellular) Antibody AG1537-025
    Expression of Neurexin 1alpha in rat PC12 cells
    Immunocytochemical staining of intact living rat pheochromocytoma (PC12) cells. A. Extracellular staining of cells using Anti-Neurexin 1α (extracellular) antibody (#AG1537), (1:50), (red). B. Merge of A with the live view of the cell.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63372
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 167923 Da
Homology Mouse, human - identical.
Additional Information
Gene ID 60391
Other Names Neurexin-1, Neurexin I-alpha, Neurexin-1-alpha, Nrxn1
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Format Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Storage After Reconstitution-20ºC.
Citations (0)

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Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.


Ushkaryov Y.A.,et al.Science 257:50-56(1992).
Ullrich B.,et al.Neuron 14:497-507(1995).
Missler M.,et al.J. Biol. Chem. 273:34716-34723(1998).
Hata Y.,et al.J. Neurosci. 16:2488-2494(1996).
Sugita S.,et al.Neuron 22:489-496(1999).

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1537-025
(40 western blots)
Availability: 2-3 weeks
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