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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Neuregulin-1 (extracellular) Antibody   

Neuregulin-1 (extracellular) Antibody

Purified Rabbit Polyclonal Antibody

  • WB - Neuregulin-1 (extracellular) Antibody AG1545-025
    Western blot analysis of rat heart lysate (lanes 1 and 4) mouse heart membranes (lanes 2 and 5) and mouse brain lysate (lanes 3 and 6):1-3.Anti-Neuregulin-1 (extracellular) antibody (#AG1545), (1:200).4-6. Anti-Neuregulin-1 (extracellular) antibody, preincubated with the control peptide antigen.
  • WB - Neuregulin-1 (extracellular) Antibody AG1545-025
    Western blot analysis of human MCF-7 breast adenocarcinoma cell lysate (lanes 1 and 4), human U87-MG glioblastoma cell lysate (lanes 2 and 5) and human MDA-231 breast adenocarcinoma cell lysate (lanes 3 and 6):1-3.Anti-Neuregulin-1 (extracellular) antibody (#AG1545), (1:200).4-6. Anti-Neuregulin-1 (extracellular) antibody, preincubated with the control peptide antigen.
  • IHC - Neuregulin-1 (extracellular) Antibody AG1545-025
    Expression of Neuregulin-1 in rat neocortex
    Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-Neuregulin-1 (extracellular) antibody (#AG1545), (1:1000), followed by anti-rabbit-biotinylated antibody and streptavidin-Cy3 (red). Neuregulin-1 staining isstrong in processes of various cell types (horizontal arrows) and less intense in neuron-shaped soma (vertical arrows). Nuclei are stained with DAPI (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02297
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 70392 Da
Homology Mouse, human - identical.
Additional Information
Gene ID 3084
Other Names Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, Neuregulin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, HRG, Neu differentiation factor, Sensory and motor neuron-derived factor, NRG1, GGF, HGL, HRGA, NDF, SMDF
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Format Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Storage After Reconstitution-20ºC.
Research Areas
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Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.


Holmes W.E.,et al.Science 256:1205-1210(1992).
Wen D.,et al.Mol. Cell. Biol. 14:1909-1919(1994).
Marchionni M.A.,et al.Nature 362:312-318(1993).
Ho W.-H.,et al.J. Biol. Chem. 270:14523-14532(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 247.00
$ 367.00
$ 475.00
Cat# AG1545-025
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