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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Neuregulin-1 Type III (extracellular) Antibody   

Neuregulin-1 Type III (extracellular) Antibody

Purified Rabbit Polyclonal Antibody

     
  • WB - Neuregulin-1 Type III (extracellular) Antibody AG1546-025
    Western blot analysis of rat dorsal root ganglion lysate:1.Anti-Neuregulin-1 Type III (extracellular) antibody (#AG1546), (1:200).2. Anti-Neuregulin-1 Type III (extracellular) antibody, preincubated with the control peptide antigen.
  • WB - Neuregulin-1 Type III (extracellular) Antibody AG1546-025
    Western blot analysis of rat brain membranes (lanes 1 and 3) and mouse brain membranes (lanes 2 and 4):1,2.Anti-Neuregulin-1 type III (extracellular) antibody (#AG1546), (1:200).3,4. Anti-Neuregulin-1 Type III (extracellular) antibody, preincubated with the control peptide antigen.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q02297
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 70392 Da
Homology Rat, mouse - identical.
Additional Information
Gene ID 3084
Other Names Pro-neuregulin-1, membrane-bound isoform, Pro-NRG1, Neuregulin-1, Acetylcholine receptor-inducing activity, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, HRG, Neu differentiation factor, Sensory and motor neuron-derived factor, NRG1, GGF, HGL, HRGA, NDF, SMDF
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Format Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Storage After Reconstitution-20ºC.
Research Areas
Citations (0)

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Background

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

References

Holmes W.E.,et al.Science 256:1205-1210(1992).
Wen D.,et al.Mol. Cell. Biol. 14:1909-1919(1994).
Marchionni M.A.,et al.Nature 362:312-318(1993).
Ho W.-H.,et al.J. Biol. Chem. 270:14523-14532(1995).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 375.00
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Cat# AG1546-025
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