|Reactivity||Human, Mouse, Rat|
|Calculated MW||40523 Da|
|Homology||Mouse - identical; human - 13/16 amino acid residues identical.|
|Other Names||Nociceptin receptor, Kappa-type 3 opioid receptor, KOR-3, Orphanin FQ receptor, ROR-C, XOR1, Oprl1, Oor, Oprl|
|Related products for control experiments||Control peptide antigen (supplied with the antibody free of charge).|
|Format||Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.|
|Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Storage After Reconstitution||The reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).|
|Control Antigen Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Control Antigen Storage After Reconstitution||-20ºC.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Fukuda K.,et al.FEBS Lett. 343:42-46(1994).
Meng F.,et al.Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
Bunzow J.R.,et al.FEBS Lett. 347:284-288(1994).
Chen Y.,et al.FEBS Lett. 347:279-283(1994).
Lachowicz J.E.,et al.J. Neurochem. 64:34-40(1995).
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