|Application ||WB, ICC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||42480 Da|
|Homology||Mouse - identical; human - 13/14 amino acid residues identical.|
|Other Names||ATP-sensitive inward rectifier potassium channel 10, ATP-sensitive inward rectifier potassium channel KAB-2, BIR10, Brain-specific inwardly rectifying K(+) channel 1, BIRK1, Inward rectifier K(+) channel Kir4.1, Potassium channel, inwardly rectifying subfamily J member 10, Kcnj10, Kab-2|
|Related products for control experiments||Control peptide antigen (supplied with the antibody free of charge).|
|Format||Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.|
|Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Storage After Reconstitution||The reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).|
|Control Antigen Storage Before Reconstitution||Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.|
|Control Antigen Storage After Reconstitution||-20ºC.|
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Provided below are standard protocols that you may find useful for product applications.
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium.
Takumi T.,et al.J. Biol. Chem. 270:16339-16346(1995).
Bond C.T.,et al.Recept. Channels 2:183-191(1994).
Bredt D.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:6753-6757(1995).
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