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>   home   >   Products   >   Primary Antibodies   >   5-Hydroxytryptamine Receptor 2A (extracellular) Antibody   

5-Hydroxytryptamine Receptor 2A (extracellular) Antibody

Purified Rabbit Polyclonal Antibody

  • WB - 5-Hydroxytryptamine Receptor 2A (extracellular) Antibody AG1596-025
    Western blot analysis of rat DRG (lanes 1 and 4), mouse brain (lanes 2 and 5) and human brain neuroblastoma SH-SY5Y lysate (lanes 3 and 6):1-3.Anti-5-Hydroxytryptamine Receptor 2A (extracellular) antibody (#AG1596), (1:200).4-6. Anti-5-Hydroxytryptamine Receptor 2A (extracellular) antibody preincubated with the control peptide antigen.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14842
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 52850 Da
Homology Mouse - identical; human - 9/13 amino acid residues identical.
Additional Information
Gene ID 29595
Other Names 5-hydroxytryptamine receptor 2A, 5-HT-2, 5-HT-2A, Serotonin receptor 2A, Htr2a, Htr2
Related products for control experimentsControl peptide antigen (supplied with the antibody free of charge).
Format Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage After ReconstitutionThe reconstituted solution can be stored at 4ºC for up to 2 weeks. For longer periods, small aliquots should be stored at -20ºC or below. Avoid multiple freezing and thawing. The further dilutions should be made using a carrier protein such as BSA (1%). Centrifuge all antibody preparations before use (10000 × g 5 min).
Control Antigen Storage Before ReconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Control Antigen Storage After Reconstitution-20ºC.
Citations (0)

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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.


Julius D.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:928-932(1990).
Pritchett D.B.,et al.EMBO J. 7:4135-4140(1988).
Liu J.,et al.Genomics 11:231-234(1991).
Fiorica-Howells E.,et al.Am. J. Physiol. 282:G877-G893(2002).

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$ 375.00
$ 475.00
$ 575.00
Cat# AG1596-025
(40 western blots)
Availability: 2-3 weeks
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