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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody - With BSA and Azide   

Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody - With BSA and Azide

Purified Mouse Monoclonal Antibody

  •  -  Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody - With BSA and Azide AH10063
    Formalin-fixed, paraffin-embedded skin stained with Cytokeratin, HMW Ab (AE-3).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04264
Other Accession P12035, P19013, P13647, P02538, P05787
Reactivity Human, Mouse, Rat
Predicted Chicken, Dog, Monkey, Rabbit
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names AE-3
Calculated MW 52-67kDa
Additional Information
Gene ID 3848
Other Names Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Hair alpha protein, Keratin-1, K1, Type-II keratin Kb1, KRT1, KRTA
Target/Specificity Solubilized keratin extract from human stratum corneum
Application Note ELISA (For coating, order Ab without BSA)
Flow Cytometry : 0.5-1ug/million cells
Immunofluorescence : 1-2ug/ml
Western Blotting : 0.5-1.0 µg/ml
Immunohistology (Frozen & formalin-fixed) : 0.5-1.0 µg/ml for 30 min at RT
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes).
Format 0.5 ml at 200ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT1
Synonyms KRTA
Function May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Cellular Location Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells
Tissue Location The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis
Research Areas
Citations (0)

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This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50’, 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.


1. Woodock-Mitchell J et. al. Journal of Cell Biology 1982;95:580-8.
2. Tseng SCG et. al. Cell 1982; 30361.

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$ 124.00
$ 324.00
$ 454.00
Cat# AH10063
(40 western blots)
Availability: 2-3 days
Bulk Size
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