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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CD28 Antibody [Clone CB28]   

CD28 Antibody [Clone CB28]

Purified Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10747
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names CB28
Calculated MW 44kDa (monomer); 88kDa (dimer)
Additional Information
Gene ID 940
Other Names T-cell-specific surface glycoprotein CD28, TP44, CD28, CD28
Target/Specificity Recombinant human CD28 protein
Application Note Flow Cytometry 2.5ul (0.5ug) per test per one million cells.
Format 0.5 ml at 200ug/ml; Conjugated to PE
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
PrecautionsCD28 Antibody [Clone CB28] is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD28
Function Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in T-cells and plasma cells, but not in less mature B-cells
Research Areas
Citations (0)

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Recognizes a glycoprotein of 44-88kDa, which is identified as CD28. It is the critical T-cell co-stimulatory receptor which provides to the cell the important second activation signal by binding CD80 and CD86 that are expressed by antigen presenting cells. Besides its co-stimulation role, CD28 functions in preventing T-cells from anergic hyporesponsive state or from undergoing premature apoptotic cell death. CD28 is also expressed on human fetal NK cells and some NK cell lines, whereas on murine NK cells the CD28 expression is much broader.


1. Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, King PD: Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6. J Immunol. 2001;166(1):197-206.
2. Scharschmidt E, Wegener E, Heissmeyer V, Rao A, Krappmann D: Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling. Mol Cell Biol. 2004;24(9):3860-73.
3. Jeong SH, Qiao M, Nascimbeni M, Hu Z, Rehermann B, Murthy K, Liang TJ. Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates. J Virol. 2004;78(13):6995-7003.

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$ 295.00
Cat# AH10130
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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