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>   home   >   Products   >   Primary Antibodies   >    DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody - With BSA and Azide   

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody - With BSA and Azide

Purified Mouse Monoclonal Antibody

  •  -  DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody - With BSA and Azide AH10151
    Formalin-fixed, paraffin-embedded human gastrointestinal stromal tumor (10X) stained with DOG1 MAb (DG1/447).
  •  -  DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody - With BSA and Azide AH10151
    Formalin-fixed, paraffin-embedded human gastrointestinal stromal tumor (20X) stained with DOG1 MAb (DG1/447).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5XXA6
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names DG1/447
Calculated MW ~114kDa
Additional Information
Gene ID 55107
Other Names Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1, DOG1, ORAOV2, TAOS2, TMEM16A
Target/Specificity Recombinant human DOG-1 protein
Application Note ELISA : For coating, order Ab without BSA
Flow Cytometry : 0.5-1ug/million cells
Immunofluorescence : 0.5-1.0 µg/ml
Western Blotting : 0.5-1.0 µg/ml
Immunoprecipitation : 0.5-1 µg/500ug protein lysate
Immunohistology (Frozen & Formalin-fixed) : 0.5-1.0 µg/ml for 30 minutes at RT
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes).
Format 0.5 ml at 200ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANO1
Synonyms DOG1, ORAOV2, TAOS2, TMEM16A
Function Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors
Tissue Location Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles
Citations (0)

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Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST’s), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST’s, including all c-kit negative GIST’s. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST’s is nearly identical: 94.4% vs. 94.7%.


1. Espinosa I, et. al. Am J Surg Pathol 2008;32:210–218.

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$ 124.00
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$ 454.00
Cat# AH10151
(40 western blots)
Availability: 2-3 days
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