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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Cytokeratin 8/18 Antibody - With BSA and Azide   

Cytokeratin 8/18 Antibody - With BSA and Azide

Purified Mouse Monoclonal Antibody

  •  -  Cytokeratin 8/18 Antibody - With BSA and Azide AH10232
    Formalin-fixed, paraffin-embedded human colon carcinoma stained with Cytokeratin 8/18 MAb (K8.8+DC10).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05787
Other Accession P05783
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa + IgG1, kappa
Clone Names K8.8 + DC10
Calculated MW 52.5kDa (CK8); 45kDa (CK18)
Additional Information
Gene ID 3856
Other Names Keratin, type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, Type-II keratin Kb8, KRT8, CYK8
Target/Specificity Keratin preparation from a human carcinoma (K8.8); PMC-42 human breast carcinoma cells (DC10)
Application Note Flow Cytometry : 0.5-1ug/million cells
Immunofluorescence : 1-2ug/ml
Immunoprecipitation : 1-2ug/500ug protein
Western Blotting : 0.5-1.0 µg/ml
Immunohistology (Frozen & Formalin-fixed) : 0.5-1.0 µg/ml for 30 min at RT
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes).
Format 0.5 ml at 200ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cytokeratin 8/18 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT8
Synonyms CYK8
Function Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Cellular Location Cytoplasm. Nucleus, nucleoplasm Nucleus matrix
Tissue Location Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
Research Areas
Citations (0)

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Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). This MAb cocktail recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. Immunohistochemical staining with this MAb is indistinguishable from that obtained with monoclonal antibody 5D3.


1. Angus B et. al. J Path, 153:377-384, 1987.
2. Angus B et. al. J Path, 155:71-75, 1988

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$ 124.00
$ 324.00
$ 454.00
Cat# AH10232
(40 western blots)
Availability: 2-3 days
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