|Application ||WB, IF, FC, IP|
|Other Names||Uroplakin-3a, UP3a, Uroplakin III, UPIII, UPK3A, UPK3|
|Target/Specificity||A synthetic peptide, aa260-279 (GASESSYTSVNRGPPLDRAE) of human UPK3A|
|Application Note||Flow Cytometry : 0.5-1ug/million cells|
Immunofluorescence : 1-2ug/ml
Western Blotting : 0.5-1.0 µg/ml
Immunoprecipitation : 1-2ug/500ug protein lysate.
|Format||0.5 ml at 200ug/ml with BSA and azide|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Uroplakin III Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).|
|Tissue Location||Expressed in ureter.|
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Provided below are standard protocols that you may find useful for product applications.
Uroplakin-3A (UPK3A) is a component of the asymmetric unit membrane (AUM). It is a highly specialized bio-membrane made by terminally differentiated urothelial cells. The protein may play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. UPK3A also contributes to the formation of urothelial glycocalyx, which may play an important role in preventing bacterial adherence through FimH bacterial protein binding leading to bladder infection. UPK3A has been shown as a helpful marker for the detection of bladder cancer.
1. Lai Y et. al. 2010. UPK3A: a promising novel urinary marker for the detection of bladder cancer. Urology 76, 514; 2009.
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