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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   p63 Antibody    

p63 Antibody

Purified Rabbit Polyclonal Antibody

  •  - p63 Antibody  AH10293-100
    Formalin-paraffin lung squamous cell carcinoma stained with p40 Rabbit PAb
  •  - p63 Antibody  AH10293-100
    Western blot analysis of p40 (p63 delta) in HEK293 lysate in 1) absence and 2) presence of immunizing peptide using p40 Rabbit PAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7Z6M1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype IgG
Clone Names N/A
Calculated MW 40kDa
Additional Information
Gene ID 10244
Other Names Rab9 effector protein with kelch motifs, 40 kDa Rab9 effector protein, p40, RABEPK, RAB9P40
Target/Specificity A synthetic peptide (ENNAQTQFSEPQY) corresponding to aa5-17 of human p40
Application Note Flow Cytometry : 0.5-1ug/million cells
Immunofluorescence : 1-2ug/ml
Western Blotting : 0.5-1.0 µg/ml
Immunoprecipitation : 1-2ug/500ug protein lysate
Immunohistology (formalin-fixed) : 1-2ug/ml for 30 minutes at RT
(Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes).
Format 0.5 ml at 200ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautionsp63 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms RAB9P40
Function Rab9 effector required for endosome to trans-Golgi network (TGN) transport.
Cellular Location Cytoplasm. Endosome membrane. Note=Interaction with PIP5K3 and subsequent phosphorylation recruits it to the endosomal membrane
Research Areas
Citations (0)

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p40 (p63 delta) is a marker recently determined to be highly specific for squamous basal cells in the immunohistochemistry (IHC) application. The current more routinely recommended marker, p63, appears to have less specificity compared to p40, especially on squamous cell tumors. The ability to differentiate between lung adenocarcinoma vs. squamous cell carcinoma is difficult and has bearing on the different therapeutic avenues for each subtype treatment. p63 antibody’s ability to distinguish between the tumor types appears to be inferior when compared to p40. The ability to utilize an antibody probe for p40 as a squamous cell marker bolsters its use for future sub-classification of lung cancers, especially by immunohistochemical techniques.


1. Bishop, JA et. al. Modern Pathology 25 : 405–415
2. Scagliotti G et. al. J Thorac Oncol 6:64–70.
3. Kargi A et. al. Appl Immunohistochem Mol Morphol 15:415–420.

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$ 295.00
Cat# AH10293-100
Availability: 2-3 days
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