Hepatocyte Specific Antigen (Hepatocellular Marker) Antibody - With BSA and Azide
Purified Mouse Monoclonal Antibody
|Application ||IHC, IF|
|Clone Names||OCH1E5; same as HepPar-1|
|Calculated MW||Unknown KDa|
|Target/Specificity||Extract of a formalin-fixed, rejected-allograft of a human liver|
|Application Note||Immunofluorescence : 0.5-1.0 µg/ml|
Immunohistology (Frozen & Formalin-fixed) : 0.5-1.0 µg/ml for 30 minutes at RT
(Staining of formalin-fixed tissues requires boiling tissue sections in 1mM EDTA, pH 7.5-8.5, for 10-20 min followed by cooling at RT for 20 minutes).
|Format||0.5 ml at 200ug/ml with BSA and azide|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Hepatocyte Specific Antigen (Hepatocellular Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
Hepatocyte Specific Antigen, also called Hepatocyte Paraffin 1 or Hep Par 1, localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC’s occur primarily in the stomach, but they are also found in many other organs. The Hepatocyte Specific Antigen may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of the Hepatocyte Specific Antigen correlates with smaller tumor size and longer patient survival. Occasionally, Hepatocyte Specific Antigen is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
1. Wennerberg AE et. al. Am J Pathol 1993;143:1050-4.
2. Ramos-Vara, J.A., et al. Histochem 2002; J. 34: 397-401.
3. Fan, Z., et al. Mod. Pathol 2003; 16: 137-144, 2003.
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