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IgA Secretory Component / ECM1 Antibody - With BSA and Azide

Purified Mouse Monoclonal Antibody

  •  -  IgA Secretory Component / ECM1 Antibody - With BSA and Azide AH10327
    Formalin-fixed, paraffin-embedded normal human small intestine stained with Secretory Component Ab (SC-05). Note cytoplasmic and membrane staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16610
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names SC05
Calculated MW ~80kDa
Additional Information
Gene ID 1893
Other Names Extracellular matrix protein 1, Secretory component p85, ECM1
Target/Specificity Secretory Component protein isolated from human colostrum
Application Note ELISA : For coating, order Ab without BSA
Flow Cytometry : 0.5-1ug/million cells
Immunofluorescence : 1-2ug/ml
Western Blotting : 0.5-1.0 µg/ml
Immunoprecipitation : 1-2ug/500ug protein lysate
Immunohistology (Frozen & Formalin-fixed) : 0.5-1.0 µg/ml for 30 minutes at RT
(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes).
Format 0.5 ml at 200ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions IgA Secretory Component / ECM1 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ECM1
Function Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
Cellular Location Secreted, extracellular space, extracellular matrix
Tissue Location Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
Research Areas
Citations (0)

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This MAb reacts with a reduction-resistant epitope present in both free and SIgA bound Secretory Component. It does not react with the cell lines lacking secretory component. The antibody is useful for studying the distribution and level of both free and bound secretory component. Secretory component is differentially expressed in epithelium, and the antibody is a popular marker for identifying subpopulations of epithelial cells and epithelial differentiation. The Secretory component antibody is a useful research tool for studying mucosal immunity, inflammation, remodeling, differentiation and tumorigenesis, all processes associated with differential secretory component expression.


1. Bartek J et. al. Histochemistry 91:235-244 (1989).

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$ 124.00
$ 324.00
$ 454.00
Cat# AH10327
(40 western blots)
Availability: 2-3 days
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Seasonal Special on Bulk Order
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