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CD45RO (T-Cell Marker) Antibody - With BSA and Azide

Purified Mouse Monoclonal Antibody

  •  -  CD45RO (T-Cell Marker) Antibody - With BSA and Azide AH10349
    Formalin-paraffin human tonsil stained with CD45RO Ab (UCHL-1).
  •  -  CD45RO (T-Cell Marker) Antibody - With BSA and Azide AH10349
    CD45RO expression by lymphocyte gated population of PBMC: PBMC were stained either with purified CD45RO Ab (UCHL-1).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08575
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a, kappa
Clone Names UCHL-1
Calculated MW 180-185kDa
Additional Information
Gene ID 5788
Other Names Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Target/Specificity Cultured human T-cells from an IL-2-dependent T-cell line (CA1)
Application Note Flow Cytometry : 5-10ul/million cells
Immunofluorescence : 1:50-1:100
Western Blotting : 1:200-1:400 for 2 hours at RT
Immunohistology (Frozen) : 1:100-1:200 for 30 min at RT.
Format 0.5 ml at 200ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD45RO (T-Cell Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD45
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Research Areas
Citations (0)

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Recognizes a 180-185kDa protein, identified as isoform of leukocyte common antigen (CD45RO) (4th Leucocyte Typing Workshop: Code No. N31). The epitope recognized by this antibody is sensitive to neuraminidase digestion. This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. It shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Reportedly, it is useful to identify T-cell lymphomas and leukemias. It rarely stains NK cells or B-cell lymphomas.


1. Knapp W, et al. Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York.
2. Ishii T, et al. 2001. P. Natl. Acad. Sci. USA 98:12138.
3. Ponsford M, et al. 2001. Clin. Exp. Immunol. 124:315.
4. Yamada M, et al. 1996. Stroke 27:1155.
5. Sakkas LI, et al. 1998. Clin. Diagn. Lab. Immunol. 5:430.

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$ 124.00
$ 324.00
$ 454.00
Cat# AH10349
(40 western blots)
Availability: 2-3 days
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