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p21WAF1 (Tumor Suppressor Protein) Antibody - With BSA and Azide

Purified Mouse Monoclonal Antibody

  •  -  p21WAF1 (Tumor Suppressor Protein) Antibody - With BSA and Azide AH10361
    Formalin-paraffin urinary transitional cell Carcinoma stained with p21 Ab (WA-1).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P38936
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Isotype IgG1, kappa
Clone Names WA-1 (same as HJ21)
Calculated MW 21kDa
Additional Information
Gene ID 1026
Other Names Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1
Target/Specificity Human recombinant p21 protein
Application Note Flow Cytometry :2.5ul (0.5ug) per test per one million cells.
Format 0.5 ml at 200ug/ml with BSA and azide
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions p21WAF1 (Tumor Suppressor Protein) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WA
Function May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Cellular Location Cytoplasm. Nucleus.
Tissue Location Expressed in all adult tissues, with 5-fold lower levels observed in the brain
Research Areas
Citations (0)

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This MAb recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk’s and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).


1. Krzywicka-Racka A & Sluder G J Cell Biol 194:199-207 (2011).
2. Folini M et al. Biochem Pharmacol 79:1781-90 (2010).

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$ 124.00
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$ 454.00
Cat# AH10361
(40 western blots)
Availability: 2-3 days
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