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CD50 / ICAM-3 Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM505 ]

     
  • IHC -  CD50 / ICAM-3 Antibody - With BSA and Azide AH10491-20
    Formalin-fixed, paraffin-embedded human Tonsil stained with CD50 Monoclonal Antibody (SPM505)
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF, FC
Primary Accession P32942
Other Accession 3385, 354563
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2b, kappa
Clone Names SPM505
Calculated MW 110-160kDa
Additional Information
Gene ID 3385
Other Names Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, CD50, ICAM3
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions CD50 / ICAM-3 Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICAM3
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha- L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Leukocytes.
Research Areas
Citations (0)
citation

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Background

Recognizes the D1 domain of an N-glycosylated glycoprotein of 120kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signaling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This MAb is excellent for staining of formalin/paraffin tissues.

References

LeukocyteTyping V (S.F. Schlossman, et al, eds.) Oxford University Press, Oxford (1995)p. 1546-1547, 1578-1579. | C.L. Holness, et al, (1995) J Biol Chem 270: 877-884. | Y. van Kooyk,et al, (1996) J Exp Med 183:1247-1252. | Leukocyte TypingVI (T. Kishimoto, et al, eds.) GarlandPublishing, Inc., New York (1997) p.403-409

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$ 219.00
$ 499.00
Cat# AH10491-20
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