Insulin-like Growth Factor-1 (IGF-1) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone SPM406 ]
|Application ||IF, FC|
|Other Accession||3479, 160562|
|Reactivity||Human, Mouse, Rat, Rabbit|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Insulin-like growth factor I, IGF-I, Mechano growth factor, MGF, Somatomedin-C, IGF1, IBP1|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Insulin-like Growth Factor-1 (IGF-1) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation.|
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Provided below are standard protocols that you may find useful for product applications.
This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.
Rotwein p, et. al. (1986) J. Biol. Chem. 261: 4828-4832. | Sandberg-Nordqvist AC, et. al. (1993) Cancer Res. 53: 2475-2478. | Zheng WH, et. al. (2000) J. Neural.Transm. Suppl. 2000: 261-272
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