Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone 2D11-H5; same as INS05 ]
|Application ||IHC-P, IF, FC|
|Other Accession||3630, 272259|
|Reactivity||Human, Mouse, Pig, Cow|
|Isotype||Mouse / IgG1, kappa|
|Clone Names||2D11-H5; same as INS05|
|Other Names||Insulin, Insulin B chain, Insulin A chain, INS|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Insulin / IRDN (beta-Cell & Insulinoma Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
de la Tour, D., et al. 2001. Mol. Endoc. 15: 476-483. | Rajagopal, J., et al. 2003. Science 299: 363. | Morisset, J., et al. 2003. J. Histochem. Cytochem. 51: 1501-1513. |
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.