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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >    Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide   

Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM259 ]

  • IHC -  Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide AH10542
    Formalin-fixed, paraffin-embedded human Skin stained with Involucrin Monoclonal Antibody (SPM259)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07476
Other Accession 3713, 516439
Reactivity Human, Pig, Dog
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM259
Calculated MW 66-170kDa
Additional Information
Gene ID 3713
Other Names Involucrin, IVL
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IVL
Function Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Cellular Location Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope
Tissue Location Keratinocytes of epidermis and other stratified squamous epithelia
Research Areas
Citations (0)

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It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ~115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.


Hudson DL, et. al. Hybridoma, 1992, 11:367-79

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$ 124.00
$ 324.00
$ 454.00
Cat# AH10542
(40 western blots)
Availability: 2-3 days
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