|Application ||IF, FC|
|Other Accession||4602, 606320|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Transforming protein Myb, V-MYB|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||c-Myb Oncoprotein Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. The v-Myb oncogene transforms immature myelomonocytic avian cells in culture and induces myeloblastosis (myeloid leukemia) in chickens.|
|Cellular Location||Host nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.
Gonda, T.J., et al. 1984. Expression of Myb, Myc and Fos proto-oncogenes during the differentiation of a murine myeloid leukaemia. Nature 310: 249-251
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