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Ornithine Decarboxylase-1 (ODC-1) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM565 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, FC |
|---|---|
| Primary Accession | P11926 |
| Other Accession | 4953, 467701 |
| Reactivity | Human, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | SPM565 |
| Calculated MW | 53kDa |
| Gene ID | 4953 |
|---|---|
| Other Names | Ornithine decarboxylase, ODC, 4.1.1.17, ODC1 |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | Ornithine Decarboxylase-1 (ODC-1) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ODC1 |
|---|---|
| Function | Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Recognizes a 53kDa protein, identified as the Ornithine Decarboxylase (ODC-1). ODC is the initial and rate-limiting enzyme in the biosynthetic pathway of polyamines and is involved in the conversion of ornithine to putrescine. The biological activity of ODC-1 is rapidly induced in response to virtually all agents known to promote cell proliferation including hormones, drugs, growth factors, mitogens, and tumor promoters. Reportedly, ODC mRNA levels are elevated in lung carcinomas as well as in colon adenomas and carcinomas. ODC activity in colorectal carcinomas is greater than those in adenomas and normal mucosa.
References
Schipper RG; Rutten RG; Sauerbeck M; Schielen WJ; Adams PJ; Kopitz J; Bohley P; Tesser GI; Verhofstad AA. Preparation and characterization of monoclonal antibodies against ornithine decarboxylase. Journal of Immunological Methods, 1993, 161(2):205-15. |
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