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>   home   >   Products   >   Primary Antibodies   >    DOG-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor Marker) Antibody - Without BSA and Azide   

DOG-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone DG1/447 + DOG-1.1 ]

  • IHC -  DOG-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor Marker) Antibody - Without BSA and Azide AH10681
    Formalin-fixed, paraffin-embedded human GIST stained with DOG1 Monoclonal Antibody (DG1/447 + DOG1.1).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q5XXA6
Other Accession 55107, 503074
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG's
Clone Names DG1/447 + DOG-1.1
Calculated MW ~114kDa
Additional Information
Gene ID 55107
Other Names Anoctamin-1, Discovered on gastrointestinal stromal tumors protein 1, Oral cancer overexpressed protein 2, Transmembrane protein 16A, Tumor-amplified and overexpressed sequence 2, ANO1, DOG1, ORAOV2, TAOS2, TMEM16A
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions DOG-1 / TMEM16A / ANO1 (Gastrointestinal Stromal Tumor Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ANO1
Synonyms DOG1, ORAOV2, TAOS2, TMEM16A
Function Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Cellular Location Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors
Tissue Location Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles
Citations (0)

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Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.


Espinosa I, et. al. Am J Surg Pathol 2008;32:210-218. |

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$ 354.00
$ 484.00
Cat# AH10681
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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