|Application ||IHC-P, IF, FC|
|Other Accession||5618, 368587|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Prolactin receptor, PRL-R, PRLR|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Prolactin Receptor (hPRL-Receptor) Antibody - Without BSA is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in breast, placenta, kidney, liver and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
It recognizes a protein of 70kDa, identified as prolactin receptor. Prolactin is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. The initial step in its action is the binding to a specific membrane receptor (prolactin receptor), which belongs to the superfamily of class 1 cytokine receptors. The function of the prolactin receptor is mediated, at least in part, by two families of signaling molecules: Janus kinases and signal transducers and activators of transcription.
Br J Cancer. 2011;104(10):1641-8. | Breast Cancer Res. 2008;10(4):R68. | Histopathology. 2008;53(1):56-61. | Mod Pathol. 2010;23(7):961-71. | Breast Cancer Res Treat. 2011;128(1):31-40
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