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Retinol Binding Protein-1 (RBP1) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM442 ]

     
  • IHC -  Retinol Binding Protein-1 (RBP1) Antibody - With BSA and Azide AH10711-20
    Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with RBP1 (SPM442)
    detail
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, IF
Primary Accession P02753
Other Accession 5947, 5948, 5950, 529571, P09455, P50120
Reactivity Human, Mouse, Rat, Rabbit, Monkey, Goat
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM442
Calculated MW 21-25kDa
Additional Information
Gene ID 5950
Other Names Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Retinol Binding Protein-1 (RBP1) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RBP4
Function Retinol-binding protein that mediates retinol transport in blood plasma (PubMed:5541771). Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).
Cellular Location Secreted
Tissue Location Detected in blood plasma and in urine (at protein level).
Research Areas
Citations (0)
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Background

Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein (RBP). Its epitope localizes between aa 74-182 of human RBP. This MAb recognizes reduced and carboxy-methylated RBP (RCM-RBP) as well as the circulatory RBP but not the native RBP, thereby suggesting that its epitope becomes accessible either on unfolding or upon binding of RBP to transthyretin (prealbumin). RBP is responsible for distributing retinol from the retinoid stores in the liver to the various target tissues. Once secreted into the blood with bound retinol, the vitamin carrier circulates complexed with transthyretin prior to vitamin delivery at the plasma membrane through a receptor-mediated mechanism.

References

Reddy BM; Karande AA; Adiga PR. Antigenic determinants of human serum retinol binding protein as probed with monoclonal antibodies. Molecular Immunology, 1993, 30(15):1355-60

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$ 219.00
$ 499.00
Cat# AH10711-20
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