Retinol Binding Protein-1 (RBP1) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone SPM442 ]
|Application ||IHC-P, IF|
|Other Accession||5947, 5948, 5950, 529571, P09455, P50120|
|Reactivity||Human, Mouse, Rat, Rabbit, Monkey, Goat|
|Isotype||Mouse / IgG1, kappa|
|Other Names||Retinol-binding protein 4, Plasma retinol-binding protein, PRBP, RBP, Plasma retinol-binding protein(1-182), Plasma retinol-binding protein(1-181), Plasma retinol-binding protein(1-179), Plasma retinol-binding protein(1-176), RBP4|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Retinol Binding Protein-1 (RBP1) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.|
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Recognizes a protein of 21kDa-25kDa, identified as retinol binding protein (RBP). Its epitope localizes between aa 74-182 of human RBP. This MAb recognizes reduced and carboxy-methylated RBP (RCM-RBP) as well as the circulatory RBP but not the native RBP, thereby suggesting that its epitope becomes accessible either on unfolding or upon binding of RBP to transthyretin (prealbumin). RBP is responsible for distributing retinol from the retinoid stores in the liver to the various target tissues. Once secreted into the blood with bound retinol, the vitamin carrier circulates complexed with transthyretin prior to vitamin delivery at the plasma membrane through a receptor-mediated mechanism.
Reddy BM; Karande AA; Adiga PR. Antigenic determinants of human serum retinol binding protein as probed with monoclonal antibodies. Molecular Immunology, 1993, 30(15):1355-60
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