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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >    Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody - Without BSA and Azide   

Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone SPM587 ]

  • IHC -  Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody - Without BSA and Azide AH10715
    Formalin-fixed, paraffin-embedded human Mantle Cell Lymphoma stained with Cyclin D1 Ab (Clone SPM587).
  • WB -  Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody - Without BSA and Azide AH10715
    Western Blot of Cyclin D1 in (1) C2C12, (2) HepG2, & (3) NIH3T3 Lysate with Cyclin D1 Ab (SPM587).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24385
Other Accession 595, 523852, 667996
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names SPM587
Calculated MW 36kDa
Additional Information
Gene ID 595
Other Names G1/S-specific cyclin-D1, B-cell lymphoma 1 protein, BCL-1, BCL-1 oncogene, PRAD1 oncogene, CCND1, BCL1, PRAD1
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCND1
Synonyms BCL1, PRAD1
Function Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Cellular Location Nucleus. Cytoplasm. Membrane. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members
Research Areas
Citations (0)

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Recognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.


Lukas J, et. al. Oncogene, 1994, 9(3):707-18. | Gillett C, et. al. Cancer Research, 1994, 54(7):1812-7. | Bartkova J, et. al. Journal of Pathology, 1994, 172(3):237-45

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$ 354.00
$ 484.00
Cat# AH10715
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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