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>   home   >   Products   >   Primary Antibodies   >   Immunology   >    HCC-4 / Liver Expressed Chemokine (LEC) Antibody - Without BSA and Azide   

HCC-4 / Liver Expressed Chemokine (LEC) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone LEC67 ]

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
E
Primary Accession O15467
Other Accession 6360, 10458
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names LEC67
Calculated MW 11kDa
Additional Information
Gene ID 6360
Other Names C-C motif chemokine 16, Chemokine CC-4, HCC-4, Chemokine LEC, IL-10-inducible chemokine, LCC-1, Liver-expressed chemokine, Lymphocyte and monocyte chemoattractant, LMC, Monotactin-1, MTN-1, NCC-4, Small-inducible cytokine A16, CCL16, ILINCK, NCC4, SCYA16
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions HCC-4 / Liver Expressed Chemokine (LEC) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCL16
Synonyms ILINCK, NCC4, SCYA16
Function Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
Cellular Location Secreted.
Tissue Location Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones
Research Areas
Citations (0)

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Background

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelo-suppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES. Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones. The ability of HCC-4 to markedly improve recognition of poorly immunogenic cells suggests that it could be an effective component of antitumor vaccines.

References

Hedrick, J.A., Helms, A., Vicari, A. and Zlotnik, A. 1998. Characterization of a novel C-C chemokine, HCC-4, whose expression is increased by inter- leukin-10. Blood 91: 4242-4247

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$ 354.00
$ 484.00
Cat# AH10733
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