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>   home   >   Products   >   Primary Antibodies   >    TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker) Antibody - With BSA and Azide   

TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker) Antibody - With BSA and Azide

Mouse Monoclonal Antibody [Clone SPM150 ]

  • IHC -  TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker) Antibody - With BSA and Azide AH10769
    Formalin-fixed, paraffin-embedded human Lung Carcinoma stained with TTF-1 Monoclonal Antibody (SPM150)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43699
Other Accession 7080, 94367
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG1, kappa
Clone Names SPM150
Calculated MW 40kDa
Additional Information
Gene ID 7080
Other Names Homeobox protein Nkx-2.1, Homeobox protein NK-2 homolog A, Thyroid nuclear factor 1, Thyroid transcription factor 1, TTF-1, Thyroid-specific enhancer-binding protein, T/EBP, NKX2-1, NKX2A, TITF1, TTF1
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions TTF-1 / NKX2.1 (Thyroid & Lung Epithelial Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKX2-1 (HGNC:11825)
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity).
Cellular Location Nucleus {ECO:0000250|UniProtKB:P50220}.
Tissue Location Thyroid and lung.
Citations (0)

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Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.ĀLoss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.


Holzinger A, et. al. Hybridoma, 1996, 15:49-53

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$ 124.00
$ 324.00
$ 454.00
Cat# AH10769
(40 western blots)
Availability: 2-3 days
Bulk Size
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