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Tyrosinase (Melanoma Marker) Antibody - Without BSA and Azide

Mouse Monoclonal Antibody [Clone T311 ]

  • IHC -  Tyrosinase (Melanoma Marker) Antibody - Without BSA and Azide AH10791
    Formalin-fixed, paraffin-embedded human Melanoma stained with Tyrosinase Monoclonal Antibody (T311).
  • IHC -  Tyrosinase (Melanoma Marker) Antibody - Without BSA and Azide AH10791
    Formalin-fixed, paraffin-embedded human Melanoma stained with Tyrosinase Monoclonal Antibody (T311).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14679
Other Accession 7299, 503555
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype Mouse / IgG2a, kappa
Clone Names T311
Calculated MW 70-80kDa
Additional Information
Gene ID 7299
Other Names Tyrosinase,, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR
Format 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
StorageStore at 2 to 8°C.Antibody is stable for 24 months.
Precautions Tyrosinase (Melanoma Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TYR
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Cellular Location Melanosome membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.


Chen Y-T, et. al. Proc. Natl. Acad. Sci. USA, 1995, 92:8125-8129

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$ 354.00
$ 484.00
Cat# AH10791
(40 western blots)
Availability: 2-3 days
Bulk Size
Seasonal Special on Bulk Order
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