Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone TA99 ]
|Application ||IHC-F, IF, FC|
|Other Accession||7306, 270279|
|Isotype||Mouse / IgG2a, kappa|
|Other Names||5, 6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, 1.14.18.-, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1, TYRP1, CAS2, TYRP, TYRRP|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAS2, TYRP, TYRRP|
|Function||Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.|
|Cellular Location||Melanosome membrane; Single- pass type I membrane protein. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex (By similarity).|
|Tissue Location||Pigment cells.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.ĀRecent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
FASEB J. 2010;24(5):1616-29. | Clin Cancer Res. 2007;13:566-75. |
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.