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von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - With BSA and Azide
Mouse Monoclonal Antibody [Clone SPM577 ]
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF, FC, IP |
|---|---|
| Primary Accession | P04275 |
| Other Accession | 7450, 440848 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse / IgG1, kappa |
| Clone Names | SPM577 |
| Calculated MW | 250kDa |
| Gene ID | 7450 |
|---|---|
| Other Names | von Willebrand factor, vWF, von Willebrand antigen 2, von Willebrand antigen II, VWF, F8VWF |
| Format | 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml. |
| Storage | Store at 2 to 8°C.Antibody is stable for 24 months. |
| Precautions | von Willebrand Factor / Factor VIII Related-Ag (Endothelial Marker) Antibody - With BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VWF |
|---|---|
| Synonyms | F8VWF |
| Function | Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| Cellular Location | Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules |
| Tissue Location | Plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
von Willebrand Factor (vWF) is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposiā€™s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.
References
Motta, A. et al. 2009. J Biomater Sci Polym Ed. 20: 1875-1897. | Germann, B. et al. 2008. Pharmazie. 63: 303-307
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