Cyclin A2 (S- & G2-phase Cyclin) Antibody - Without BSA and Azide
Mouse Monoclonal Antibody [Clone E67 ]
|Application ||IF, FC|
|Other Accession||890, 58974|
|Reactivity||Human, Mouse, Cow, African Green Monkey|
|Isotype||Mouse / IgG2a, kappa|
|Other Names||Cyclin-A2, Cyclin-A, CCNA2, CCN1, CCNA|
|Format||200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.|
|Storage||Store at 2 to 8°C.Antibody is stable for 24 months.|
|Precautions||Cyclin A2 (S- & G2-phase Cyclin) Antibody - Without BSA and Azide is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.|
|Cellular Location||Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER|
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Provided below are standard protocols that you may find useful for product applications.
It recognizes a protein of 54kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdkā€™s) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdkā€™s. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.
Adamczewski JP; Gannon JV; Hunt T. Simian virus 40 large T antigen associates with cyclin A and p33cdk2. Journal of Virology, 1993, 67(11):6551-7
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